• Taube/Koret Center for Neurodegenerative Disease Research

About The Taube/Koret Center

The goal of the Taube-Koret Center for Neurodegenerative Disease Research (TKC) is to establish a translational research and development center that will undertake an ambitious task of preventing, treating, and curing neurodegenerative diseases; such as Huntington’s disease, Parkinson’s disease, Amyotrophic lateral sclerosis, Frontotemporal Dementia. The center aims to achieve this goal with innovative programs that targets a critical gap between the discovery of putative targets, which typically occurs in academia, and the development of safe and effective drugs, which require the resources and expertise of industry. The TKC research program will consist of a target validation and drug development program and a target/drug discovery program. Both will benefit from access to experienced individuals with extensive industrial and drug development expertise and to highly experienced Contract Research Organization (CRO) providers.

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Stem cells have amazing promise for making replacement tissues and organs. However, while that application might be some years in the future, stem cells have already proved to be a welcome breakthrough for neurodegenerative disease research. This is particularly true for a specific type of stem cells called induced pluripotent stem cells or iPSCs that were discovered by Gladstone investigator Shinya Yamanaka.


ALS Association Golden West Chapter

The ALS Association Golden West Chapter organized a tour of the Taube/Koret Center at the Gladstone Institutes directed by Dr. Steven Finkbeiner. The tour was an opportunity for some the chapter's key stakeholders, including people diagnosed with ALS, caregivers, family members, volunteer fundraiseres and philanthropists, to learn about the groundbreaking scientific discoveries that are being supported by the ALS Asssociation; through annual programs such as  the Walk to Defeat ALS, the Napa Ride to Defeat ALS, and other major gifts and special programs.

Finkbeiner Lab scientist Dr. Ashkan Javaherian and his team are using autophagy to better understand the mechanics of ALS — and to develop potential new ALS therapies.